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Our Approach

Every assessment we perform is drawn from the same diagnostic toolkit used in academic gastroenterology.

Functional and mechanical gut symptoms are among the most common, and most under-tested, presentations in medicine. Not because the science doesn't exist to explain them, but because the specific testing required is rarely accessible in a standard practice setting. GI Diagnostics exists to close that gap, as a dedicated testing resource for patients and the physicians who treat them.

Diagnostic Testing 01

SIBO Breath Testing

Hydrogen & Methane Lactulose Breath Test
Rome IV Diagnostic Criteria
North American Consensus Guidelines

Small intestinal bacterial overgrowth is among the most common and most underdiagnosed explanations for chronic digestive symptoms. Breath testing is the non-invasive standard for detecting it, and the pattern of results matters as much as the numbers themselves.

Method
Lactulose breath challenge, clinical-grade device
Duration
2–3 hours in studio
Gases measured
Hydrogen (H₂) and Methane (CH₄)
Preparation
Low-fermentation diet prior, 12-hour fast

The small intestine is designed to be relatively sterile. When bacteria migrate upstream from the colon, the result is fermentation of carbohydrates before they can be properly absorbed. The gas produced is detectable in exhaled breath.

Hydrogen vs. methane, why the distinction matters
Pattern
Clinical Association
Hydrogen-dominant
Loose stools, diarrhea-predominant IBS, bloating, early satiety
Methane-dominant (IMO)
Constipation, slow transit, abdominal distension that doesn't resolve
Mixed pattern
Alternating bowel habits, bloating regardless of stool pattern

Methane production is classified as Intestinal Methanogen Overgrowth (IMO) under Rome IV guidance. The distinction from hydrogen-dominant SIBO matters clinically, they respond to different interventions and are managed differently.

Commonly Ordered For

Patients with bloating, gas, abdominal discomfort, irregular bowel habits, or symptoms that worsen after eating, particularly carbohydrate-rich meals. Also indicated where a prior IBS diagnosis hasn't been explained by structural workup, or with a history of prior gut surgery, motility disorders, or prolonged antibiotic or PPI use.

Diagnostic Testing 02

Carbohydrate Malabsorption Panel

Lactose · Fructose · Sucrose
Substrate-Specific Breath Challenge

Breath-based carbohydrate malabsorption testing replaces elimination diets and guesswork with objective, quantitative data on enzyme and transport function.

Method
Substrate-specific breath challenge
Duration
2–3 hours per substrate tested
Substrates available
Lactose, Fructose, Sucrose
Preparation
Substrate-specific restrictions, 12-hour fast

This panel measures a specific thing: the small intestine's capacity to digest and absorb particular carbohydrates. It is not an immune or IgG panel. It measures the enzymatic and transport function that determines whether a substrate is absorbed or fermented.

Why each substrate is tested independently
Substrate
Mechanism & Presentation
Lactose
Lactase enzyme insufficiency. Bloating, cramping, loose stools 30 to 120 minutes after dairy. Often partial rather than complete.
Fructose
GLUT5 transporter insufficiency. Bloating and loose stools after fruit or high-fructose foods. Dose-dependent.
Sucrose
Sucrase-isomaltase deficiency. Frequently missed. Triggered by table sugar, starch, processed foods.
Commonly Ordered For

Anyone who suspects particular foods are triggering symptoms but can't confirm a clear pattern. Especially relevant where symptoms follow eating but vary unpredictably, or where a prior elimination diet has produced incomplete relief.

Diagnostic Testing 03

Wireless Motility Capsule Study

Whole-Gut Transit Time Analysis
Regional Transit Mapping
Wireless Motility Telemetry

The wireless motility capsule is the only way to objectively measure how quickly, and in which specific segments, content moves through the gastrointestinal tract. It distinguishes presentations that look identical clinically but require different treatment.

Method
Ingestible wireless capsule, continuous regional data
Duration
Multi-day data collection, normal daily activity
Regions mapped
Gastric emptying, small bowel, colonic transit

The capsule captures continuous data as it travels through each region of the gut. The physiological changes it detects along the way allow precise identification of regional transit times, data that no breath test, imaging study, or symptom diary can generate.

What regional transit times reveal
Region
Clinical Significance
Gastric emptying
Normal: 2–5 hours
Delayed emptying drives nausea, early satiety, bloating. Rapid emptying produces dumping-type symptoms.
Small bowel transit
Normal: 3–8 hours
Rapid transit delivers excess substrate to the colon, worsening fermentation. Slow transit favors bacterial overgrowth.
Colonic transit
Normal: 18–59 hours
Colonic inertia versus normal-transit constipation requires different management. This distinction requires transit data.
Commonly Ordered For

Patients with chronic constipation, nausea, early satiety, unexplained bloating, or bowel habits that haven't responded to dietary changes. Also indicated where SIBO findings suggest an underlying motility component explaining recurrence.

Diagnostic Testing 04

High-Resolution Manometry

Esophageal & Anorectal Pressure Mapping
Chicago Classification v4.0
High-Definition Pressure Topography

Manometry maps the muscular mechanics of the gastrointestinal tract in real time, capturing coordinated pressure events that imaging, endoscopy, and breath testing cannot see.

Method
High-resolution pressure-sensing catheter
Duration
45–90 minutes per region
Regions studied
Esophagus (with LES), Anorectum (EAS, IAS, puborectalis)
Classification
Chicago v4.0 (esophageal); Rome IV-informed (anorectal)

High-resolution manometry uses a catheter lined with closely spaced pressure sensors to generate a continuous, spatially resolved picture of pressure activity. The result shows not just whether muscles are contracting, but where, in what sequence, with what force, and whether sphincters respond appropriately.

Esophageal Manometry
Disorder
Presentation
Achalasia (Types I–III)
Impaired LES relaxation, absent peristalsis. Progressive dysphagia, regurgitation, chest discomfort.
EGJ Outflow Obstruction
Elevated LES pressure with incomplete relaxation. Overlaps clinically with achalasia; distinguished by pattern.
Hypercontractile Esophagus
Markedly elevated contraction force. Chest pain and dysphagia that may mimic cardiac symptoms.
Ineffective Peristalsis
Failed coordinated contraction. Associated with reflux, regurgitation, slow esophageal clearance.
Anorectal Manometry

Anorectal manometry evaluates pressure relationships and coordination between the internal and external anal sphincters, the puborectalis muscle, and the rectum. It identifies dyssynergic defecation, a paradoxical pelvic floor contraction during straining that is among the most common and most commonly missed causes of chronic constipation. Imaging does not capture it. Manometry does.

Commonly Ordered For

Esophageal: patients with persistent dysphagia, unexplained chest pain, or reflux unresponsive to standard therapy. Anorectal: patients with chronic constipation, particularly straining and incomplete evacuation, or anorectal pain unexplained by colonoscopy or imaging.

How Testing Is Selected

These tests are most informative when read together.

A SIBO breath test and a motility study are related conversations. Slow small bowel transit creates conditions where bacterial overgrowth is more likely to establish and persist. Treating the SIBO without understanding the transit picture can produce temporary improvement followed by recurrence.

This is why every engagement begins with a thorough intake. Your symptom history and the pattern of your presentation determine which combination of testing produces the most complete and actionable picture, for you and for the physician who will treat you.

4805 NW 2nd Avenue
Boca Raton, FL 33431

(561) 961-0208
questions@gi-diagnostics.com

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